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Updated: May 12, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
Published on: May 22, 2014
Recent advances in structural studies of NLRP3 and NLRP1 inflammasome regulation
Zhikuan Zhang1, Toshiyuki Shimizu1
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Abstract:
The NOD-like receptor (NLR) family comprises inflammasome sensors that are critical intracellular pattern recognition receptors of the innate immune system. The NLR family members NLRP3 and NLRP1 can be activated by a wide range of pathogenic, chemical, self-derived and stress-related stimuli. In recent years, remarkable progress in functional and structural studies of these two receptors have shed light on their complicated and entirely different activation and regulation mechanisms. This review focuses on recent structural studies of NLRP3 and NLRP1, emphasizing the regulatory steps mediated by various activation and inhibitory factors.
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