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Mussel-inspired multifunctional gelatin microgel for accelerating full-thickness wound healing
Lijing Teng1, Honghong Zhang2, Xiaomin Sun1
1School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guian New District, Guiyang 561113, China; Key Laboratory of Biology and Medical Engineering, Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, Immune Cells and Antibody Engineering Research Center in University of Guizhou Province, Guizhou Medical University, Guian New District, Guiyang 561113, China; Engineering Research Center of Intelligent Materials and Advanced Medical Devices, School of Biology and Engineering, Guizhou Medical University, Guian New District, Guiyang 561113, China.
This study introduces a new polydopamine functionalized gelatin microgel (PGM) for efficient wound healing. This injectable microgel promotes tissue adhesion, cell migration, and healing without drugs.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Complete wound healing is hindered by bleeding, inflammation, and infection.
- Developing advanced wound care materials is crucial for clinical practice.
Purpose of the Study:
- To develop an injectable, mussel-inspired polydopamine functionalized gelatin microgel (PGM) for efficient wound healing.
- To evaluate the adhesive properties, multifunctional performance, and efficacy of PGM in a full-thickness skin defect model.
Main Methods:
- PGM was synthesized using a simple emulsification-chemical crosslinking technique.
- The microgel's size (15-100 microm), adhesion strength (10.3 kPa to porcine skin), and biocompatibility were assessed.
- In vivo studies utilized a full-thickness skin defect model in rodents.
Main Results:
- PGM exhibited controllable size generation and excellent adaptability to complex wound geometries.
- The microgel demonstrated significant hemostatic activity, promoted cell migration, and scavenged reactive oxygen species.
- PGM treatment down-regulated TNF-a, enhanced collagen regeneration, and increased CD31 expression, leading to effective skin wound healing.
Conclusions:
- The developed injectable PGM offers a drug-free strategy for efficient full-thickness wound healing.
- PGM shows significant potential for clinical applications in advanced wound management.
