Establishing altitude-based coagulation reference ranges in Western Sichuan.

Area of Science:

• Physiology
• Environmental Health
• Hematology

Background:

• Plateau regions present unique physiological challenges including hypoxia and low temperatures.
• Standard hematological indicators may not accurately reflect health status in high-altitude populations.
• Altitude, sex, and age are critical factors influencing physiological parameters.

Purpose of the Study:

• To analyze coagulation results in relation to altitude, sex, and age on the Western Sichuan Plateau.
• To identify patterns of change in coagulation indicators across different altitudes and demographic groups.
• To establish altitude-specific normal ranges for coagulation parameters.

Main Methods:

• Coagulation indicators were measured in healthy individuals across four altitudes (1,400m to 4,100m).
• Participants were stratified by sex and age groups (<40, 40-59, ≥60 years).
• Statistical analysis examined associations between coagulation, altitude, age, and sex.

Main Results:

• Coagulation indicators showed significant variations influenced by altitude, sex, and age.
• Specific trends in coagulation parameters were observed with increasing altitude.
• Distinct patterns of coagulation changes were identified for different sexes and age groups.

Conclusions:

• Altitude, sex, and age significantly impact coagulation function in plateau residents.
• Established normal ranges provide a crucial reference for diagnosing and treating diseases in high-altitude regions.
• This research offers a scientific foundation for improved healthcare strategies in plateau environments.