Palladium-catalyzed sequential [3+2] cyclization/C-H activation of o-iodostyrenes with cyclopropenones as C2 synthons
Jie Sun1, Shaojie Zhang1, Ruixue Wang1
1College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, P. R. China. wuxinxng@163.com.
Abstract:
Herein, we report a novel palladium-catalyzed synthesis of diverse dihydroindeno[2,1-a]indenes by the reaction of o-iodostyrenes with cyclopropenones. This protocol involves a [3+2] cyclization/C-H activation sequence, forming a C(sp2)-C(sp2) and two C(sp2)-C(sp3) bonds. This procedure represents an innovative method for the assembly of tetracyclic dihydroindeno-indenes utilizing cyclopropenones as a new C2 synthon.
More Related Videos
Related Concept Videos
Cycloaddition Reactions: Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cycloaddition Reactions: MO Requirements for Photochemical Activation
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)

