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A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and
Rintaro Yoshitake1,2, Syunsuke Taguchi1, Yoshimasa Harada1
1Nagahama Red Cross Hospital Nagahama Japan.
Introduction:
Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.
Case Presentation:
A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.
Conclusion:
This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.
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