Related Experiment Video

Updated: May 12, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
00:07

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.2K

New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis

Jianxiong Xu1, Chen Gao2

  • 1Department of Radiation Oncology, The First Hospital of Putian City, Putian, Fujian, China.

Discover Oncology
|May 8, 2025
PubMed
Abstract

Insights

Researchers identified LY75 and S100A12 as potential new therapeutic targets for papillary thyroid carcinoma (PTC). Multi-omics analysis explored their roles in PTC development, offering new avenues for treatment.

Area of Science:

  • Oncology
  • Genomics
  • Proteomics

Background:

  • Papillary thyroid carcinoma (PTC) treatment faces challenges, necessitating the discovery of novel therapeutic targets.
  • Current therapeutic strategies for PTC require enhancement through innovative approaches.

Purpose of the Study:

  • To identify novel therapeutic targets for papillary thyroid carcinoma (PTC) using a multi-omics approach.
  • To investigate the potential mechanistic roles of identified targets in PTC pathogenesis.

Main Methods:

  • Proteomic Mendelian randomization (MR) analysis integrated genome-wide association studies (GWAS) and protein quantitative trait loci (pQTL) data.
  • Analysis utilized proteomic data from deCODE and UK Biobank Protein Project (UKB-PP), alongside PTC GWAS data from the Finnish Consortium.
  • eQTL validation, bioinformatics differential analysis, and mediation analysis were employed to identify and validate therapeutic targets and their mechanisms.

Main Results:

  • Two potential therapeutic targets, LY75 and S100A12, were identified as significantly associated with papillary thyroid carcinoma (PTC).
  • Mediation analysis provided insights into the potential mechanistic pathways through which LY75 and S100A12 may influence PTC pathogenesis.

Conclusions:

  • Multi-omics analysis successfully identified novel potential therapeutic targets for papillary thyroid carcinoma.
  • The study elucidated potential underlying mechanisms of identified targets, paving the way for future therapeutic development in PTC.
Keywords:
Bioinformatics analysesCis-pQTLEQTLMediationMendelian randomizationPapillary thyroid carcinoma

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.5K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K