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Choroid plexus volume and association with migraine Pathophysiology.
Jianmei Xiong1, Mengqi Liu2, Xin Li3
1Department of Neurology, Hainan Hospital of PLA General Hospital, Sanya 572013, China.
European Journal of Radiology
|May 8, 2025
Summary
Choroid plexus volume changes differ between episodic and chronic migraine patients. Normalized choroid plexus to lateral ventricle volume (CP/LV) may serve as an imaging biomarker for migraine diagnosis.
Area of Science:
- Neuroimaging
- Neurology
- Medical Diagnostics
Background:
- Direct evidence linking choroid plexus structures to migraine pathophysiology is limited.
- Understanding peripheral-central interactions in migraine requires further investigation into specific brain structures.
Purpose of the Study:
- To quantitatively assess choroid plexus volume changes in episodic and chronic migraine patients compared to controls.
- To explore differences in choroid plexus volume between migraine subtypes and controls.
Main Methods:
- Brain MRI (3.0 T) was used to examine 65 participants (18 episodic migraine, 16 chronic migraine, 31 controls).
- Choroid plexus volume was segmented using FreeSurfer and normalized as the choroid plexus to ipsilateral lateral ventricle volume (CP/LV) ratio.
- Receiver operating characteristic (ROC) curve analysis assessed the diagnostic accuracy of CP/LV for migraine prediction.
Main Results:
- Migraine patients exhibited higher anxiety, depression, headache burden, and cognitive impairment.
- Significant group differences in right-sided CP/LV were observed.
- CP/LV decreased in episodic migraine but increased in chronic migraine patients.
- Right-sided CP/LV differentiated episodic migraine from controls (AUC 0.696) and aided in distinguishing chronic from episodic migraine (AUC 0.715).
Conclusions:
- Dynamic alterations in lateral ventricular choroid plexus volume are implicated in migraine pathogenesis.
- Normalized CP/LV is associated with distinct migraine subtypes.
- Normalized CP/LV shows potential as an imaging biomarker for migraine diagnosis.
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