Prostate cancer and pollution: Dangerous connections

Prostate cancer is the archetypal hormone-dependent cancer in men, mirroring breast cancer in women. The increase in its prevalence over time raises questions, and occupational exposure data, particularly among agricultural workers, have shown a probable or possible link with exposure to certain endocrine disruptors. The best-known of these is probably chlordecone, used in the French West Indies and responsible for an increased risk of prostate cancer. Outside these situations of occupational and/or acute exposure, it is more difficult to prove that endocrine disruptors are responsible for prostate cancer, particularly through epidemiological studies, the interpretation of which is still difficult. Animal models, in particular murine models, have demonstrated the role of fetal or early neonatal exposure in the development of prostate cancer in adulthood. In vitro models, meanwhile, are shedding light on the mechanisms involved in tumor promotion and progression, involving both classic hormone receptors (AR, ER) and other new signaling pathways. The aim of this review is to report the available data showing the link between exposure to endocrine disruptors and the risk of prostate cancer.