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Updated: May 12, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photocatalytic Dual-Defluorination Thiolation of Trifluoromethyl Hydrazones
Wen-Jie Pan1,2, Wei-Guo Cao1, Ji-Chang Xiao2
1Department of Chemistry, Innovative Drug Research Center, Shanghai University, 200444 Shanghai, China.
Abstract:
The defluorination of trifluoromethyl groups typically involves breaking one or all three C-F bonds, while selectively cleaving exactly two C-F bonds presents a considerable challenge. In this work, we present a method for the sequential defluorination of trifluoromethyl hydrazones under photocatalytic conditions, which involves the specific breakage of two C-F bonds followed by thiolation to yield monofluorinated alkenes containing a thiol group. Transforming trifluoromethyl-containing polyfluoroalkyl substances into fluorinated non-PFAS compounds holds potential practical implications.
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