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Identification of Increased Tissue microRNA-214 Expression Level as a Potential Prognostic Biomarker for Gastric
Hao Wang1, Baoru Qiao2, Huanbin Yang1
1Department of Gastrointestinal Surgery, Wuhan Fourth Hospital, Wuhan, Hubei, China.
Annals of Clinical and Laboratory Science
|May 9, 2025
Summary
Overexpression of microRNA-214 (miR-214) in gastric cancer tissues correlates with advanced disease and poor survival. MiR-214 may serve as a novel prognostic biomarker for gastric cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are crucial in cancer development and progression.
- miR-214 has been implicated in promoting gastric cancer cell proliferation, migration, and invasion.
- Understanding miR-214's clinical significance is vital for gastric cancer management.
Purpose of the Study:
- To investigate the clinical significance of miR-214 expression in gastric cancer.
- To evaluate the prognostic value of miR-214 in gastric cancer patients.
Main Methods:
- Quantitative real-time PCR (qRT-PCR) to measure miR-214 levels in 133 gastric cancer tissues and adjacent normal tissues.
- Chi-square tests to assess associations with clinicopathological parameters.
- Kaplan-Meier and Cox regression analyses for survival evaluation.
Main Results:
- miR-214 was significantly upregulated in gastric cancer tissues compared to normal tissues (P<0.001).
- High miR-214 expression correlated with deeper invasion, poorer differentiation, lymph node metastasis, and advanced TNM stage.
- Elevated miR-214 predicted reduced overall survival and was an independent prognostic factor (P=0.033).
Conclusions:
- miR-214 is closely linked to gastric cancer occurrence, progression, and metastasis.
- Overexpressed miR-214 in tissues shows potential as a prognostic biomarker for gastric cancer.
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