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Knowledge, Use, and Misuse of Self-Prescribed Doxycycline Postexposure Prophylaxis in a Community-Based Preexposure
Roberto Rossotti, Enrico Caruso1, Daniele Calzavara1
1Milano Checkpoint ETS, Milan, Italy.
Sexually Transmitted Diseases
|May 9, 2025
Summary
Awareness of doxycycline postexposure prophylaxis (doxyPEP) is low among those using preexposure prophylaxis. Few users are aware of or utilize doxyPEP, highlighting a need for better implementation and guidelines.
Area of Science:
- Public Health
- Infectious Diseases
- Sexual Health
Background:
- Preexposure prophylaxis (PrEP) is a key HIV prevention strategy.
- Doxycycline postexposure prophylaxis (doxyPEP) is emerging as a tool to prevent bacterial STIs.
- Understanding doxyPEP knowledge and usage is crucial for effective implementation.
Purpose of the Study:
- To assess awareness and current usage of doxycycline postexposure prophylaxis (doxyPEP) among individuals using preexposure prophylaxis (PrEP).
- To identify barriers and facilitators to doxyPEP adoption and correct usage.
Main Methods:
- A survey was conducted among 703 respondents who were users of preexposure prophylaxis.
- Data collected included awareness of doxycycline postexposure prophylaxis, usage patterns, and discussions with healthcare providers.
Main Results:
- Only 28.2% of respondents were aware of doxycycline postexposure prophylaxis (doxyPEP).
- Actual usage of doxyPEP was reported by only 8.8% of participants.
- One quarter discussed doxyPEP with medical doctors, and 51.6% adhered to recommended dosing.
Conclusions:
- There is a significant gap in awareness and utilization of doxycycline postexposure prophylaxis (doxyPEP) among PrEP users.
- Effective implementation strategies and clear guidelines are necessary to promote appropriate doxyPEP use.
- Further education for both patients and healthcare providers is recommended.
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