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Replacement as an aging intervention
Sierra Lore1,2, Jesse R Poganik3, Anthony Atala4
1Buck Institute for Research on Aging, Novato, CA, USA.
Nature Aging
|May 9, 2025
Summary
Aging research lacks human interventions, but replacement strategies like tissue engineering and prosthetics show promise. Exploring biological and synthetic replacements could offer new avenues for healthy aging interventions.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Gerontology
Background:
- Aging research has advanced understanding of aging mechanisms but lacks proven human interventions.
- Replacement therapies (e.g., joint replacements, transplants) effectively restore function in disease/injury.
Purpose of the Study:
- To explore biological and synthetic replacement strategies as potential interventions for aging.
- To review innovations in tissue engineering, cell therapies, xenotransplantation, and synthetic approaches.
Main Methods:
- Discussed innovations in tissue engineering (scaffolds, bioprinting).
- Reviewed genetic engineering for donor-recipient compatibility, cell therapies, and xenotransplantation.
- Explored synthetic approaches: prostheses, external devices, brain-machine interfaces.
- Evaluated heterochronic parabiosis and age-mismatched transplants for systemic benefits.
Main Results:
- Tissue engineering, cell therapies, and xenotransplantation show potential for functional tissue generation and compatibility.
- Synthetic approaches offer functional restoration and integration with biological systems.
- Evidence from parabiosis and transplants suggests potential systemic benefits from age-mismatched approaches.
Conclusions:
- Replacement strategies, both biological and synthetic, represent a promising, albeit challenging, frontier for aging interventions.
- Advancing these therapies requires addressing scalability, ethical considerations, and further research into systemic effects.
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