Disseminated intravascular coagulation--the clinician's dilemma

Disseminated intravascular coagulation is a complex syndrome involving inappropriate activation of the coagulation and subsequently fibrinolytic systems. It may occur in conjunction with a variety of disease states. The diagnosis must be based on a series of laboratory tests which provide indirect evidence of the process. Treatment consists of general supportive measures and elimination of the activating source of the coagulopathy. Additional therapy is dictated by individual circumstances.