Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

19.8K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
19.8K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

927
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
927

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kidney Health in a Changing Climate: Emerging Disease Patterns and Driving Mechanisms.

Kidney360·2026
Same author

<i>In vitro</i> generation of RORγt<sup>+</sup> regulatory T cells reveals enhanced immunosuppressive function and OXPHOS-dependent metabolism.

Frontiers in immunology·2026
Same author

Birth Weight Measurement Gaps and Global Kidney Health.

Kidney360·2026
Same author

Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.

Nature communications·2026
Same author

The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.

Journal of the American Society of Nephrology : JASN·2026
Same author

Extracellular Vesicles Facilitate the Crosstalk Between High Glucose-Stimulated Mesangial Cells and Healthy Podocytes to Mediate Injury Responses.

International journal of molecular sciences·2026

Related Experiment Video

Updated: May 12, 2025

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

1.9K

The intelligent podocyte: sensing and responding to a complex microenvironment.

John F Bertram1,2, Luise A Cullen-McEwen1, Vinicius Andrade-Oliveira3,4

  • 1Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.

Nature Reviews. Nephrology
|May 9, 2025
PubMed
Summary

Podocytes sense and respond to their kidney microenvironment to maintain blood filtration. Dysregulation of these processes can lead to kidney disease.

More Related Videos

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

10.9K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

296

Related Experiment Videos

Last Updated: May 12, 2025

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Author Spotlight: Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

1.9K
Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
12:19

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

10.9K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

296

Area of Science:

  • Nephrology
  • Cell Biology
  • Physiology

Background:

  • Podocytes are crucial cells within the kidney's glomerular filtration barrier.
  • They operate in a unique microenvironment subjected to mechanical forces and molecular exchange.
  • Podocyte survival and function depend on sensing and responding to environmental cues.

Purpose of the Study:

  • To elucidate the sensing and response mechanisms of podocytes to their microenvironment.
  • To understand how podocyte functions impact overall kidney health.

Main Methods:

  • The study reviews podocyte interactions with the extracellular matrix and neighboring cells.
  • It examines various signaling pathways involved in environmental sensing.
  • Analysis includes the role of organelles in regulating podocyte responses.

Main Results:

  • Podocytes sense environmental factors like glucose, lipids, oxygen, pH, and pressure.
  • Response mechanisms involve signaling pathways and organelle functions.
  • These responses regulate cell metabolism, immune function, and podocyte structure.

Conclusions:

  • Podocyte sensing and response are vital for maintaining glomerular and kidney health.
  • Imbalances in these processes contribute to inflammation, podocyte loss, and glomerular diseases.