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Published on: August 12, 2019
Transition Metal-Catalyzed Aminocarbonylation Reactions
Fatemeh Doraghi1, Mohammad Hossein Morshedsolouk1,2, Niki Raisi3
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
None:
Transition-metal-catalyzed aminocarbonylation reactions using low-cost and accessible CO gas as a C1 building block and amine as a nucleophile have been widely used to prepare amides, which are broadly exist in bioactive drugs, natural products, and polymers. This type of reaction has also been applied to construct various biologically active heterocycles. In this review, we highlight aminocarbonylation reactions involving amine and CO under various transition metal catalysis systems (palladium, rhodium, ruthenium, iridium, iron, copper, and cobalt) over the past decade.
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