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Consensus Recommendations for Hyperpolarized [1-13C]pyruvate MRI Multi-center Human Studies.

Shonit Punwani1,2, Peder Ez Larson3, Christoffer Laustsen4

  • 1Department of Radiology, University College London Hospital NHS Foundation Trust, London, UK.

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|May 9, 2025
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Summary
This summary is machine-generated.

Consensus on best practices for multi-center human studies using hyperpolarized (HP) [1-13C]pyruvate MRI was established. Experts agreed on key aspects of preparation, acquisition, and analysis for reproducible metabolic imaging.

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Area of Science:

  • Medical Imaging
  • Metabolic Imaging
  • Hyperpolarized Contrast Agents

Background:

  • Hyperpolarized (HP) [1-13C]pyruvate MRI enables in-vivo metabolic assessment.
  • Its translation into multi-center human studies necessitates standardized best practices.

Purpose of the Study:

  • To establish consensus on best practices for multi-center human studies using HP [1-13C]pyruvate MRI.
  • To provide recommendations for reproducible clinical applications.

Main Methods:

  • A 2-round formal consensus-building exercise involving 29 experts from 13 sites.
  • Experts covered pharmacy methods, MR physics, translational imaging, and data analysis.
  • 246 statements were evaluated across four key areas.

Main Results:

  • Consensus was reached on approximately two-thirds of statements.
  • Agreement was found on release criteria for HP pyruvate preparation and the need for phantom-based site qualification and consistent field strength.
  • Preference for normalized metabolite area-under-curve (AUC) values and metabolite AUC as key metrics was established.

Conclusions:

  • Areas of consensus for multi-center HP [1-13C]pyruvate MRI studies were confirmed.
  • Further research is needed to define best practices in areas lacking full agreement.