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Noninvasive Brain Stimulation for Opioid Use Disorder: An Update of the Literature
Sophia H Blyth1, Carri Polick2,3, Lena Kim1
1Department of Psychiatry and Behavioral Science, Vanderbilt University Medical Center, Nashville, TN.
Purpose Of Review:
Although medications for opioid use disorder (OUD) are effective, relapse remains common. Noninvasive brain stimulation (NIBS) has emerged as a potential adjunctive treatment. We review publications since 2020 that tested NIBS interventions in humans and assessed clinically relevant outcomes.
Recent Findings:
We identified a total of 19 studies of NIBS for treatment of craving; acute detoxification, withdrawal, and early abstinence; relapse prevention; cognitive dysfunction associated with OUD; mood and anxiety symptoms in OUD; co-occurring SUDs with OUD; and post-operative pain management and prevention of OUD.
Summary:
NIBS interventions, particularly repetitive transcranial magnetic stimulation and transcranial direct current stimulation have demonstrated preliminary evidence of effectiveness to treat OUD and its associated symptoms.
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