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Serum IgE level in systemic lupus erythematosus.

K Mikecz, I Sonkoly, C Mészáros

    Acta Medica Hungarica
    |January 1, 1985
    PubMed
    Summary

    Serum total-immunoglobulin E (IgE) levels are higher in active systemic lupus erythematosus (SLE) than in remission. However, elevated IgE is not a reliable indicator of SLE disease activity due to complex influencing factors.

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    Serum and urinary cytokine levels of SLE patients.

    Die Pharmazie·2012

    Area of Science:

    • Immunology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
    • Immunoglobulin E (IgE) plays a role in allergic reactions and immune responses.
    • The role of IgE in SLE pathogenesis requires further investigation.

    Purpose of the Study:

    • To investigate the significance of serum total-IgE levels in patients with SLE.
    • To determine if serum total-IgE levels correlate with disease activity in SLE.

    Main Methods:

    • Serum samples were collected from SLE patients during active disease and remission.
    • Total IgE levels were quantified using standardized immunoassays.
    • Statistical analysis was performed to compare IgE levels between disease states.

    Main Results:

    • Serum total-IgE levels were significantly higher in the active stage of SLE compared to remission.
    • A wide variation in IgE levels was observed, indicating complex regulatory mechanisms.
    • The findings suggest that IgE levels do not follow a simple distribution pattern in SLE.

    Conclusions:

    • While serum total-IgE levels tend to increase during active SLE, they are not a definitive biomarker for disease activation.
    • Multiple factors influence IgE production, complicating its interpretation in SLE.
    • Further research is needed to elucidate the precise role of IgE in SLE.

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