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Updated: May 12, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
An efficient nanoreactor reverses the tumor immunosuppressive microenvironment through synergetic dual-route
Mingchao Xia1, Hanxiang Li1, Yuhang Wang1
1College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, P. R. China. qduyuzz@qdu.edu.cn.
None:
Tumors being immunologically cold is the main reason for the unsatisfactory clinical performance of cancer immunotherapy. An efficient nanoreactor was developed to reverse the tumor immunosuppressive microenvironment. This nanoreactor can effectively convert intracellular glucose and GSH into ROS and H2S in tumors for enhanced chemodynamic therapy and complete energy metabolism block through synergistic dual-route reactions, consequently leading to efficient immunogenic cell death and eliciting a robust immune response.
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