Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical vascular organoid therapy promotes microvascular regeneration and functional recovery in porcine ischemic cardiomyopathy.

Stem cell reports·2026
Same author

Characterization of induced pluripotent stem cell lines from patients of African American ancestry.

Stem cell research·2026
Same author

Impact of leaflet stiffness in aortic valve neocuspidization in ex vivo biomechanical simulation.

JTCVS open·2026
Same author

Generation of two induced pluripotent stem cell lines from hypertrophic cardiomyopathy patients carrying MYBPC3 mutations.

Stem cell research·2026
Same author

New approach methodologies for drug discovery.

Cell·2026
Same author

Survival Benefit of Heart-Kidney Versus Heart Transplant With or Without Delayed Kidney Transplant.

Journal of the American Heart Association·2026

Related Experiment Video

Updated: Jun 14, 2025

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
11:14

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Published on: August 13, 2014

18.3K

Silk Fibroin Methacrylation: Chemical Synthesis to Biomechanical Optimization in Tissue Engineering.

Catherine A Wu1, Yuanjia Zhu1,2, Y Joseph Woo1,2

  • 1Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305, United States.

ACS Biomaterials Science & Engineering
|May 9, 2025
PubMed
Summary

Silk fibroin, a natural biomaterial, can be chemically modified with methacrylate agents to enhance its properties for tissue engineering. This review explores methacrylated silk fibroin

Keywords:
Silk fibroingelatin methacryloylglycidyl methacrylatemethacrylationmethacrylic anhydridetissue engineering

More Related Videos

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
08:28

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers

Published on: September 4, 2017

9.8K
In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films
06:11

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Published on: February 26, 2019

8.5K

Related Experiment Videos

Last Updated: Jun 14, 2025

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
11:14

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Published on: August 13, 2014

18.3K
Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers
08:28

Microfluidic Dry-spinning and Characterization of Regenerated Silk Fibroin Fibers

Published on: September 4, 2017

9.8K
In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films
06:11

In Vivo Targeted Expression of Optogenetic Proteins Using Silk/AAV Films

Published on: February 26, 2019

8.5K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Tissue engineering requires biomaterials with optimized biological, chemical, physical, and mechanical properties.
  • Silk fibroin is a promising natural biomaterial with suitable intrinsic characteristics.
  • Chemical modification of silk fibroin enhances its biophysical properties for advanced applications.

Purpose of the Study:

  • To provide a comprehensive review of methacrylated silk fibroin (SF) as a biomaterial.
  • To discuss the synthesis, characterization, and applications of methacrylated SF in tissue engineering.
  • To highlight current challenges and future directions in methacrylated SF research.

Main Methods:

  • Review of existing literature on silk fibroin modification and tissue engineering applications.
  • Analysis of synthesis techniques for creating methacrylated silk fibroin.
  • Examination of characterization methods for assessing methacrylated SF properties.

Main Results:

  • Methacrylate modification, using agents like glycidyl methacrylate, methacrylic anhydride, and gelatin methacryloyl, significantly improves silk fibroin's biophysical properties.
  • Methacrylated SF demonstrates potential in bone, cartilage, skin, and nerve tissue engineering.
  • Current understanding of methacrylate agent effects on specific cell types is limited.

Conclusions:

  • Methacrylated silk fibroin is a versatile biomaterial with broad tissue engineering applications.
  • Further in vivo investigations are needed to address cell-specific responses and tissue-specific needs.
  • The methacrylated SF platform holds significant promise for future advancements in regenerative medicine.