A study of compositae plant extract reactions in photosensitivity dermatitis

In subjects with chronic photosensitivity of the photosensitivity dermatitis/actinic reticuloid type the persistent reaction of the skin appears to be due to a number of factors, including those of contact allergic sensitivity and of photosensitivity (i.e., phototoxicity and/or photoallergy). The assessment of the relevant importance of these factors can be complicated by the reactivity of the skin resulting in false positive responses from skin patch and photopatch testing. Moreover, difficulties may also arise in the assessment of the results using commercially available patch test materials. However, the study described here indicated that, provided the reactivity of the skin is suppressed prior to investigation, reliable results are obtained from photopatch testing and that these results are similar whether the extract is from a commercial source or has been obtained from locally grown Compositae plants. Also, that although there may be a photoallergic component in the cutaneous photosensitivity, the results of the in vivo and in vitro studies reported here indicate the likely involvement of phototoxicity as well.