Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiandrogens and insulin sensitizers in PCOS management.

Minerva obstetrics and gynecology·2025
Same author

Robotic secondary cytoreduction in recurrent ovarian cancer: a tailored approach for kidney transplant recipients.

Facts, views & vision in ObGyn·2025
Same author

Invasive vulvar extramammary Paget's disease with extensive posterior involvement: a multidisciplinary surgical and reconstructive challenge-case-based video report.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2025
Same author

Robotic-assisted uterine transposition for fertility preservation in patients treated with radiotherapy for pelvic malignancies: from transposition to repositioning.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2025
Same author

Assessing the Accuracy of Large Language Models on European Guidelines for Cervical Cancer: An In Silico Benchmarking Study.

BJOG : an international journal of obstetrics and gynaecology·2025
Same author

Predictors of Successful Neoadjuvant Chemotherapy and Interval Cytoreductive Surgery in Management of Ovarian Cancer.

JCO oncology practice·2025

Related Experiment Video

Updated: May 12, 2025

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.2K

Enhancing surgical precision in ovarian cancer with FRα-fluorescence-guided surgery.

Filippo Alberto Ferrari1, Marcello Ceccaroni1, Giovanni Scambia2

  • 1Department of Obstetrics and Gynecology, Gynecologic Oncology and Minimally Invasive Pelvic Surgery, International School of Surgical Anatomy (ISSA), IRCCS "Sacro Cuore - Don Calabria" Hospital, Negrar di Valpolicella, Verona, Italy.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|May 9, 2025
PubMed
Summary
This summary is machine-generated.

Folate receptor alpha (FRα)-targeted imaging aids ovarian cancer surgery by improving tumor detection. Pafolacianine (OTL38) shows significant promise in identifying more lesions, enhancing complete tumor removal.

Keywords:
Fluorescence-guided surgeryFolate receptor alpha (FRα)OTL38Ovarian cancerPrecision oncology

More Related Videos

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

8.1K
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.1K

Related Experiment Videos

Last Updated: May 12, 2025

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
06:37

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Published on: October 20, 2010

23.2K
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

8.1K
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.1K

Area of Science:

  • Oncology
  • Surgical Imaging
  • Molecular Imaging

Background:

  • Complete cytoreduction is crucial for advanced ovarian cancer prognosis.
  • Folate receptor alpha (FRα)-targeted intraoperative fluorescence imaging enhances tumor localization.
  • Agents like pafolacianine (OTL38) and EC17 improve visualization beyond standard methods.

Purpose of the Study:

  • To systematically review the safety, efficacy, and feasibility of FRα-targeted fluorescence imaging in ovarian cancer surgery.
  • To evaluate the impact of FRα-targeted agents on intraoperative lesion detection and complete cytoreduction.
  • To compare the performance of OTL38 and EC17 in identifying malignant lesions.

Main Methods:

  • Systematic review of PubMed, Scopus, and Web of Science.
  • Inclusion of clinical and preclinical studies on FRα-targeted agents with fluorescence modalities.
  • Bias assessment using Cochrane Risk of Bias Tool and Newcastle-Ottawa Scale.

Main Results:

  • Eleven studies analyzed, including clinical and preclinical trials.
  • OTL38 improved lesion detection by 29%, identifying additional lesions in 33% of patients (sensitivity >85%).
  • EC17 identified 16% more lesions, but autofluorescence was a challenge; adverse events were mild.

Conclusions:

  • FRα-targeted imaging can enhance lesion detection and increase resection completeness in cytoreductive surgery for ovarian cancer.
  • OTL38 demonstrates significant potential, supported by larger trials, while EC17 shows feasibility.
  • Future research should focus on optimizing imaging agents and assessing survival outcomes.