Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases.

Science translational medicine·2026
Same author

Electroactive microneedle augmented stem cell therapy in myocardial infarction.

Science advances·2026
Same author

Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration.

Nature biomedical engineering·2026
Same author

Biorhythm-mimicking growth hormone patch.

Nature materials·2025
Same author

A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models.

Science translational medicine·2024
Same author

An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases.

Nature communications·2023
Same journal

Correction to "Nanoparticles (NPs)-Meditated LncRNA AFAP1-AS1 Silencing to Block Wnt/β-Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Femtosecond-Laser Nanocavitation Regenerates SERS-Active Plasmonic Nanogaps for Longitudinal Molecular Sensing at Biointerfaces.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Correction to "Bioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Non-Line-of-Sight Passive Ammonia Sensor Loaded With MXene/In<sub>2</sub>O<sub>3</sub> Composites for Agricultural Products Quality Deterioration Detection.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Cerium Nanoparticle-Mediated Inhibition of the NSUN2/m<sup>5</sup>C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Biomimetic Nanoplatform for Dual Target Nano-Metabolic Therapy in Diabetes-Associated Biofilm Infections.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: May 12, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.3K

Microneedle Patch for In Situ Neutrophil Monitoring.

Ziyi Lu1,2,3, Ruisi Cai2, Tianao Xie1,3

  • 1Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|May 9, 2025
PubMed
Summary
This summary is machine-generated.

A novel microneedle patch offers a non-invasive method for monitoring neutrophil levels, crucial for diagnosing diseases and managing treatments. This technology provides rapid, convenient detection without blood sampling, benefiting patients in remote areas.

Keywords:
cancermicroneedleneutrophil monitoringnon‐invasive detectionportable device

More Related Videos

Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood
10:13

Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood

Published on: June 3, 2014

11.2K
Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions
08:41

Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions

Published on: May 10, 2022

1.4K

Related Experiment Videos

Last Updated: May 12, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.3K
Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood
10:13

Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood

Published on: June 3, 2014

11.2K
Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions
08:41

Imaging Neutrophil Migration in the Mouse Skin to Investigate Subcellular Membrane Remodeling Under Physiological Conditions

Published on: May 10, 2022

1.4K

Area of Science:

  • Biomedical Engineering
  • Medical Diagnostics
  • Nanotechnology

Background:

  • Neutrophil monitoring is vital for disease diagnosis and treatment management (e.g., chemotherapy).
  • Current complete blood count methods are invasive and impractical for frequent monitoring.
  • There is a need for rapid, non-invasive neutrophil detection methods.

Purpose of the Study:

  • To develop a button-like microneedle patch for rapid, non-invasive neutrophil level detection.
  • To validate the patch's performance in vitro and in vivo.
  • To assess the patch's utility in analyzing patient-derived fluids.

Main Methods:

  • A microneedle patch with a vacuum chamber for interstitial fluid extraction.
  • Colorimetric detection using a myeloperoxidase-sensitive hydrogel.
  • Mobile phone application for data recording and quantification.
  • In vitro and in vivo validation using a rat model and patient fluids.

Main Results:

  • The microneedle patch successfully detected neutrophil levels non-invasively.
  • Validated performance in a chemotherapy-induced neutropenic rat model.
  • Achieved precise measurements in human urine and abdominal drainage fluid.

Conclusions:

  • The developed microneedle patch enables convenient, in situ neutrophil monitoring without blood sampling.
  • This technology can serve as a valuable alternative to routine blood counts, particularly in resource-limited settings.
  • Potential to improve patient care through accessible and frequent neutrophil level assessment.