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Updated: May 12, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Testosterone Replacement Therapy for Testosterone Deficiency in Older Men
Amber McMahon1, Richard J Fantus1
1Department of Urology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
None:
This review explores the increasing use of testosterone therapy in aging men, driven by the need to address age-related symptoms like decreased libido, muscle weakness, and anemia. Studies such as the Testosterone Trials and Testosterone Replacement Therapy for Assessment of Long-term Vascular Events and Efficacy Response in Hypogonadal Men trial show that testosterone therapy can offer benefits in sexual function, physical performance, and bone density, with no significant increase in risks for cardiovascular events or prostate cancer. However, conflicting data suggest that careful, individualized treatment is necessary, especially in older men with existing health conditions.
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