Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

154
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
154
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

319
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
319
Disorders of the Urinary System01:20

Disorders of the Urinary System

176
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
176
Urinary Bladder01:23

Urinary Bladder

233
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
233
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

35
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Affecting Implementation of the EQUIPPED Medication Safety Program for Older Veterans in the Emergency Department: A Qualitative Analysis.

Journal of the American Geriatrics Society·2026
Same author

The cost-effectiveness of the stopping elderly accidents, deaths and injuries options randomised quality improvement trial to prevent falls among older adults.

Age and ageing·2026
Same author

"It Felt Like Throwing in the Towel": Family Caregiver Perspectives on End-of-Life Decision Making in Chronic Obstructive Pulmonary Disease.

Journal of palliative medicine·2026
Same author

Associations between psychological and trauma-related factors and urinary incontinence severity and treatment response among women veterans.

American journal of obstetrics and gynecology·2026
Same author

Are Bladder-Related Knowledge and Agentic Beliefs Associated With Bladder Health?

Urogynecology (Philadelphia, Pa.)·2026
Same author

An integrated behavioral treatment for improving nocturia and insomnia symptoms in older adults (MINT): study protocol for a multi-site randomized clinical trial.

Trials·2026

Related Experiment Video

Updated: May 12, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.0K

Voiding Dysfunction and Parkinson Disease in Geriatric Patients.

Camille P Vaughan1

  • 1Division of Geriatrics & Gerontology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Birmingham/Atlanta VA Geriatric Research Education and Clinical Center, Atlanta VA Health Care System, Atlanta, GA, USA.

Clinics in Geriatric Medicine
|May 9, 2025
PubMed
Summary

Urinary symptoms like overactive bladder are common in Parkinson disease (PD), increasing patient burden and risks. Lifestyle changes and careful medication review are key for managing these nonmotor symptoms.

Keywords:
Behavioral treatmentDrug treatmentNocturiaOveractive bladderParkinson disease

More Related Videos

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

810
Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

1.8K

Related Experiment Videos

Last Updated: May 12, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.0K
Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

810
Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

1.8K

Area of Science:

  • Neurology
  • Urology

Background:

  • Overactive bladder symptoms are frequent nonmotor issues in Parkinson disease (PD).
  • These symptoms exacerbate the challenges of living with PD, increasing fall and institutionalization risks.

Purpose of the Study:

  • To review management strategies for overactive bladder symptoms in Parkinson disease.
  • To highlight the importance of considering comorbidities and differential diagnoses.

Main Methods:

  • Literature review of current evidence on managing urinary symptoms in PD.
  • Analysis of treatment options including behavioral, pharmacological, and surgical approaches.

Main Results:

  • Lifestyle and behavioral therapies, such as pelvic floor muscle exercises, are effective initial treatments.
  • Medication management requires careful assessment of comorbidities like falls, constipation, sleep issues, and orthostatic hypotension to prevent adverse events.
  • Distinguishing idiopathic PD from other parkinsonian conditions is crucial for surgical intervention success.

Conclusions:

  • Integrated management of urinary symptoms is essential for improving quality of life in Parkinson disease patients.
  • A thorough patient assessment, considering comorbidities and specific parkinsonian diagnoses, guides optimal treatment selection.