[Pediatric cutaneous mesenchymal tumors: How to cope with small samples?]

This review article deals with the diagnosis of superficial mesenchymal tumours in children. This is not a comprehensive review, but it focuses on the issue of diagnosis on small samples, especially on fine needle biopsies, which are more and more frequent. A selection of difficult diagnostic situations are discussed, including the case of spindle-cell tumours with variable adipocytic component, some fibrohistiocytic tumours, myofibromas, and vascular tumours. The key messages are the technical requirements in relation to the small sample size, the essential nature of clinical data in paediatric pathology and primarily the age, which is crucial not only for establishing the differential diagnosis but also for choosing the relevant ancillary techniques, and last, the utility of cytogenetics, mainly FISH, and of wisely used molecular biology techniques.