Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Emerging Medications in Facial Nerve Recovery: A Systematic Review and Meta-Analysis.

OTO open·2026

Same author

Trauma-Informed Care for Voice, Airway, and Swallowing Disorders: A Scoping Review.

ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses·2026

Same author

Quality and Reliability of YouTube Videos for Patient Education in Stapedectomy and Stapedotomy.

Ear, nose, & throat journal·2026

Same author

In Response to Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis.

The Laryngoscope·2026

Same author

Thyroid Cancer Risk in Patients With Type 2 Diabetes Taking Glucagon-Like Peptide 1 Receptor Agonists.

OTO open·2026

Same author

The Use of Fibrin Sealants in Reducing Postoperative Complications in Skull Base Surgery: A Systematic Review and Meta-Analysis.

Journal of neurological surgery. Part B, Skull base·2026

Search research articles

Related Experiment Video

Updated: May 12, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis.

Andrew Meci¹, Neerav Goyal^1,2, David Goldenberg^1,2

¹The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

The Laryngoscope

|May 10, 2025

Summary

Oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSF) have higher malignant transformation rates to oral squamous cell carcinoma (OSCC) than previously thought. These findings highlight the critical need for vigilant monitoring and timely intervention for oral premalignant disorders (OPMD).

Keywords:

database study oral leukoplakia oral lichen planus oral squamous cell carcinoma submucous fibrosis

More Related Videos

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

Related Experiment Videos

Last Updated: May 12, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

Area of Science:

Oral pathology
Oncology
Public health

Background:

Oral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSF) are recognized precancerous oral premalignant disorders (OPMD).
Previous estimates of malignant transformation rates to oral squamous cell carcinoma (OSCC) are based on limited data.
This study provides the largest analysis to date on OPMD malignant transformation rates.

Purpose of the Study:

To determine the 5-year malignant transformation rates of OL, OLP, and OSF to OSCC.
To compare these rates with a control cohort.
To analyze treatment pathways and survival outcomes for patients with OPMD.

Main Methods:

Retrospective cohort study utilizing the TriNetX database.
Inclusion of patients aged 18+ diagnosed with OL, OLP, or OSF between 2008-2018.
Analysis of 5-year follow-up data for OSCC transformation, treatment, and survival.

Main Results:

A total of 59,204 patients were included.
The 5-year malignant transformation rates were 15.6% for OL, 1.4% for OLP, and 18.6% for OSF.
The overall 5-year malignant transformation rate for OPMD was 6.2%, significantly higher than controls (p < 0.01).

Conclusions:

Malignant transformation rates for OL, OLP, and OSF are higher than previously reported.
Elevated transformation rates for OL and OSF necessitate close patient monitoring and prompt treatment.
The 5-year survival probability for patients with OPMD was 94.3%.