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Updated: Jul 1, 2026

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Published on: May 5, 2020

Emerging Medications in Facial Nerve Recovery: A Systematic Review and Meta-Analysis.

Kimberly Chan¹, Cheng Ma¹, Bao Y Sciscent²

¹Department of Otolaryngology-Head and Neck Surgery Pennsylvania State University College of Medicine Hershey Pennsylvania USA.

|June 30, 2026

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This review found nimodipine improved facial nerve function scores but did not significantly increase recovery rates. Other therapies like pentoxifylline show potential for facial nerve regeneration.

Area of Science:

Neurology
Regenerative Medicine
Pharmacology

Background:

Facial nerve injuries can lead to significant functional deficits.
Medical therapies are being explored to enhance facial nerve regeneration and recovery.
Systematic review of current evidence is needed to guide clinical practice.

Purpose of the Study:

To systematically review medical therapies for promoting facial nerve regeneration and recovery.
To evaluate the efficacy of various pharmacological agents in human studies.
To synthesize findings through qualitative and meta-analysis.

Main Methods:

Searched PubMed/Medline, Embase, and SCOPUS databases for English-language studies up to May 2025.
Included human studies assessing medical therapy efficacy using validated facial nerve grading scales (e.g., HB score).

Keywords:

Bell's palsy calcium channel blockers facial nerve regeneration facial paralysis medications

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Last Updated: Jul 1, 2026

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration

Published on: May 5, 2020

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

Performed qualitative analysis on nine studies and meta-analysis on six.

Main Results:

Nimodipine improved House Brackmann (HB) scores but did not significantly increase recovery rates (HB score ≤3) compared to controls.
Nimodipine significantly decreased HB scores pre- and post-treatment.
Pentoxifylline and extracellular vesicles showed some efficacy, while co-enzyme Q10 was not effective.

Conclusions:

Nimodipine shows potential for improving facial nerve function but requires further investigation for significant recovery.
Pentoxifylline and extracellular vesicles may offer therapeutic benefits for facial nerve regeneration.
Co-enzyme Q10 is not effective; more research is needed for novel treatments.