Micro-Nano Convergence-Driven Radiotheranostic Revolution in Hepatocellular Carcinoma

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Radiotherapy is crucial for hepatocellular carcinoma (HCC) treatment, particularly for non-surgical candidates.
• Tumor hypoxia and radioresistance limit radiotherapy efficacy and cause side effects.
• Nanotechnology offers novel micro-nano drug delivery systems to improve HCC radiotherapy.

Purpose of the Study:

• To review recent advancements in micro-nanomaterial applications for HCC radiotherapy.
• To analyze the role of micro-nanomaterials in radiosensitization and radioimmunotherapy.
• To explore the clinical translation potential of these materials.

Main Methods:

• Literature review of micro-nanomaterial applications in HCC treatment.
• Systematic analysis of radiosensitization mechanisms.
• Evaluation of clinical translation challenges and opportunities.

Main Results:

• Micro-nanomaterials show promise in enhancing external and internal radiotherapy for HCC.
• These materials can overcome tumor hypoxia and radioresistance, improving treatment outcomes.
• Challenges remain regarding in vivo safety and metabolism of micro-nanomaterials.

Conclusions:

• Micro-nanomaterials represent a significant advancement in improving HCC radiotherapy.
• Further research on safety and metabolism is essential for successful clinical translation.
• These materials hold potential for combination therapies like radioimmunotherapy.