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Tagatose-1,6-Bisphosphate Aldolases, the Unloved DHAP-Aldolases
Christine Guérard-Hélaine1, Léo Paulat1, Marielle Lemaire1
1Clermont-Auvergne INP, Institut de Chimie de Clermont-Ferrand, Université Clermont Auvergne, CNRS, F-63000, Clermont-Ferrand, France.
Abstract:
Tagatose-1,6-bisphosphate aldolases (TagA) have been understudied. The limited publications on the subject report a poor stereoselectivity, which quickly leads to their classification among the less interesting aldolases. This conclusion, which appears inadequate, discourages further investigation by other researchers. The objective here is to re-examine all these studies in detail to finally uncover inconsistencies and unexplained observations regarding the behavior of these enzymes. Ultimately, there is a significant lack of research that can deepen the understanding of TagA, which will likely reveal its potential to be as valuable as its counterparts: fructose-1,6-bisphosphate, rhamnulose-1-phosphate, and fuculose-1-phosphate aldolases.
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