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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Flexible porous microneedle array for bioelectric skin patch.

Soichiro Tottori¹, Mirai Matsuura², Sae Ichinose¹

¹Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, Japan.

Biomedical Microdevices

|May 10, 2025

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Flexible microneedle patches offer improved drug delivery and ionic current pathways. This innovation enhances adaptability to skin curvature, reducing transdermal resistance for effective bioelectric applications.

Area of Science:

Biomedical Engineering
Materials Science
Dermatology

Background:

Porous microneedles facilitate transdermal drug delivery and ionic current.
Conventional microneedle arrays are rigid, limiting application on curved skin.
Flexibility is crucial for effective microneedle-based transdermal therapies.

Purpose of the Study:

To develop a flexible porous microneedle array integrated onto a flexible substrate.
To evaluate the impact of flexibility on skin adaptability and transdermal ionic resistance.
To create a novel microneedle-based bioelectric skin patch for stimulation and drug delivery.

Main Methods:

Direct integration of porous microneedles onto a flexible substrate.
Numerical and analytical modeling to assess transdermal resistance reduction.

Keywords:

Flexible device Iontophoresis Porous microneedle Skin patch

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Combination with an enzymatic battery to form a bioelectric skin patch.

Main Results:

The flexible microneedle array conforms to curved skin surfaces.
Reduced transdermal ionic resistance was achieved with the flexible array.
A stable transdermal current was generated by the microneedle-based bioelectric skin patch.

Conclusions:

Flexible porous microneedle arrays enhance adaptability and reduce transdermal resistance.
The developed bioelectric skin patch is suitable for transdermal stimulation and drug delivery.
This technology offers a promising platform for advanced transdermal applications.