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Updated: May 29, 2025

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery
Gaobo Wang1,2, Natsuho Moriyama3, Soichiro Tottori2
1Department of Biomedical Engineering, School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, China.
Abstract:
Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing and drug delivery, achieve enhanced functionality when combined with iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing and precise drug delivery within closed-loop systems. These integrated platforms represent a major advancement in personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments in iontophoresis-assisted microneedles for transdermal biosensing, drug delivery, and closed-loop applications. It delves into the mechanisms of iontophoresis, assesses its advantages and limitations, and explores future directions for these transformative technologies.
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