Novel Nanozymes with Sample Pretreatment Function for Specific Multimodal Detection of Perfluorooctanesulfonate
Yi Yang1, Huipeng Sun1, Taihe Han1
1State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
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Perfluorooctanesulfonate (PFOS), a ubiquitous and persistent organic pollutant, poses severe health risks due to its bioaccumulation and recalcitrance. Despite existing detection methods, the need for rapid, sensitive, and cost-effective PFOS quantification remains unmet, particularly for on-site and mass sample analysis. Here, we introduce an innovative "three-in-one" multifunctional nanohybrid, Fe3O4@MON-F@Ru, which revolutionizes the detection of PFOS through a novel integration of nanozymes and microporous organic networks (MONs). This nanohybrid enables sensitive colorimetric and photothermal signaling for PFOS detection, addressing the long-standing challenge of selectivity in nanozyme-based analytical methods. The Fe3O4 core enables magnetic separation, while the fluorinated MONs shell specifically interacts with PFOS through F-F bonding and electrostatic forces, concurrently serving as a high-density carrier for Ru nanozymes. The presence of PFOS significantly inhibits catalytic activity, offering a rapid and specific colorimetric method with a detection limit as low as 15.4 nM. Additionally, based on the near-infrared (NIR) laser-driven photothermal properties of oxidized 3,3',5,5'-tetramethylbenzidine (TMB), the photothermal analysis for PFOS detection was also established. This study not only advances the design of nanozymes with integrated sample pretreatment capabilities but also pioneers a portable, dual-signaling sensing strategy for PFOS detection, offering profound implications for environmental monitoring and public health safety.
