Related Experiment Video
Updated: May 13, 2025

Single-cell Microinjection for Cell Communication Analysis
Published on: February 26, 2017
Intercepting Modes of Cellular Communication
Kristin E Claflin1, Matthew J Potthoff2
1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Abstract:
Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication, which contributes to the progression of metabolic disease including obesity, hepatic steatosis, and type II diabetes. In this collection of Cellular and Molecular Gastroenterology and Hepatology, we highlight new advances in transcellular and interorgan communication, particularly in the liver and gastrointestinal (GI) tract, and how impairments in these biologic networks contribute to metabolic disease. In addition, we emphasize the therapeutic potential for modulating these communication pathways to treat metabolic disease.
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