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Related Concept Videos

Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Types of Signaling Molecules01:32

Types of Signaling Molecules

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In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...
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Autocrine Signaling01:01

Autocrine Signaling

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Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
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Contact-dependent Signaling01:19

Contact-dependent Signaling

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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
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Cell-surface Signaling01:21

Cell-surface Signaling

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Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
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Single-cell Microinjection for Cell Communication Analysis
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Single-cell Microinjection for Cell Communication Analysis

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Intercepting Modes of Cellular Communication.

Kristin E Claflin1, Matthew J Potthoff2

  • 1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Cellular and Molecular Gastroenterology and Hepatology
|May 10, 2025
PubMed
Summary
This summary is machine-generated.

Maintaining metabolic homeostasis relies on organ system communication. Disruptions in this communication worsen metabolic diseases like obesity and diabetes, but offer therapeutic targets.

Keywords:
CommunicationGutHepatokinesLiverMASHMetabolism

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Area of Science:

  • Gastroenterology and Hepatology
  • Metabolic Disease Research
  • Cellular and Molecular Biology

Background:

  • Metabolic homeostasis depends on intricate communication networks within and between organ systems for nutrient regulation.
  • Metabolic dysfunction impairs tissue communication, driving diseases such as obesity, hepatic steatosis, and type II diabetes.

Purpose of the Study:

  • To highlight advances in transcellular and interorgan communication, focusing on the liver and gastrointestinal tract.
  • To explore how impaired biologic communication networks contribute to metabolic disease progression.
  • To emphasize the therapeutic potential of modulating these communication pathways for metabolic disease treatment.

Main Methods:

  • Review of recent scientific literature and research findings.
  • Analysis of cellular and molecular mechanisms underlying interorgan communication.
  • Focus on liver and gastrointestinal tract signaling pathways.

Main Results:

  • New insights into transcellular and interorgan communication pathways.
  • Demonstration of the link between impaired communication and metabolic disease.
  • Identification of therapeutic targets within these communication networks.

Conclusions:

  • Dysfunctional communication in the liver and GI tract is a key factor in metabolic diseases.
  • Modulating these communication pathways presents a promising therapeutic strategy for metabolic disorders.
  • Further research into these networks can lead to novel treatments for obesity, hepatic steatosis, and type II diabetes.