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Updated: May 13, 2025

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
Published on: October 22, 2015
Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies
Jiayi Xu1, Daria Igudesman2, Laura M Huckins1
1Department of Psychiatry, Yale School of Medicine, 60 Temple Street, Suite 7A, New Haven, CT 06510, USA.
Abstract:
Anorexia nervosa (AN) is a debilitating and often refractory eating disorder that is unique among psychiatric disorders insofar as nutrition is key to recovery. Treatment options and efficacy are limited with no approved medications for AN. Genetic studies are clarifying the etiology of AN, with the goal of eventually informing the development of innovative personalized pharmacologic, nutritional, microbial, and behavioral interventions. We present the current state of genome-wide and epigenome-wide association studies, gut microbiome research, and functional genomics investigations and discuss translating this knowledge into clinical practice.
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