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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Acute Kidney Injury in Latin America
Rolando Claure-Del Granado1, Raúl Lombardi2, Jonathan Chávez-Íñiguez3
1Division of Nephrology, Hospital Obrero No 2-Caja Nacional de Salud, Cochabamba, Bolivia; Instituto de Investigaciones Biomédicas, Facultad de Medicina, Universidad Mayor de San Simón, Cochabamba, Bolivia.
Seminars in Nephrology
|May 10, 2025
Summary
Acute kidney injury (AKI) is a significant health problem in Latin America, driven by socioeconomic factors and limited resources. Addressing these challenges requires improved prevention, early detection, and regional research collaboration.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Acute kidney injury (AKI) presents a substantial global health burden, with disproportionately high morbidity and mortality in Latin America.
- Prevalence is elevated in rural and underserved populations, linked to socioeconomic disparities, prevalent comorbidities like diabetes and hypertension, and environmental factors.
Purpose of the Study:
- To review the distinct epidemiology, risk factors, and healthcare system challenges associated with AKI in Latin America.
- To highlight the need for region-specific strategies to mitigate the impact of AKI.
Main Methods:
- Comprehensive literature review of AKI epidemiology and management in Latin America.
- Analysis of risk factors, including infections, nephrotoxins, and socioeconomic determinants.
- Assessment of healthcare system limitations, diagnostic accessibility, and treatment availability.
Main Results:
- AKI is prevalent in Latin America, influenced by socioeconomic disparities, comorbidities, infections (e.g., tropical diseases), and nephrotoxin exposure.
- Significant hurdles in AKI management include limited diagnostics, variable practices, workforce shortages, and constrained access to renal replacement therapies.
- Research is hindered by data gaps and funding limitations, impeding the development of effective interventions.
Conclusions:
- Urgent public health initiatives for AKI prevention, screening, and early detection are crucial.
- Multicenter collaborations and tailored regional guidelines are essential for improving AKI outcomes.
- Addressing infrastructural and economic constraints is vital to enhance AKI care and reduce its burden in Latin America.
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