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Optimizing Pediatric Asthma Management: Implementation and Evaluation of Anti-Inflammatory Reliever and Single

Thinh H Nguyen1, Megan Elios2, Anne M Fitzpatrick3

  • 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.

The Journal of Allergy and Clinical Immunology. in Practice
|May 11, 2025
PubMed

Insights

Anti-inflammatory reliever (AIR) and single maintenance and reliever (SMART) therapies show promise for childhood asthma. This review examines their risks, benefits, and challenges in young children, aiming to improve asthma management.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Pharmacology

Background:

  • Asthma is a common chronic respiratory condition in children.
  • Anti-inflammatory reliever (AIR) and single maintenance and reliever (SMART) therapies are established for adult and adolescent asthma.
  • Limited evidence exists for AIR and SMART therapies in younger children.

Purpose of the Study:

  • To review current evidence on the risks and benefits of AIR and SMART therapies in pediatric asthma.
  • To identify challenges in applying AIR and SMART therapies to young children.
  • To propose solutions for improved pediatric asthma management using these therapies.

Main Methods:

  • Systematic literature review of studies on AIR and SMART therapies in children.
  • Analysis of safety and efficacy data for pediatric populations.
  • Identification and categorization of implementation challenges and potential solutions.

Main Results:

  • Evidence for AIR and SMART therapy safety and efficacy in early childhood is still evolving.
  • Common challenges include dosing, monitoring, and adherence in young children.
  • Potential solutions involve tailored protocols and enhanced caregiver education.

Conclusions:

  • AIR and SMART therapies hold potential for improving childhood asthma management.
  • Further research is needed to establish definitive safety and efficacy profiles in young children.
  • Addressing identified challenges can facilitate wider adoption of these advanced asthma therapies for pediatric patients.

Keywords:
Anti-inflammatory reliever therapyAsthma treatment guidelinesBarriers to AIR and SMARTInhaled corticosteroids in childrenPediatric asthma managementShort-acting β(2)-agonistsSingle maintenance and reliever therapyasthma control

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