Comprehensive strategies for overcoming dental biofilms: Microbial dynamics and innovative methods
Selvaraj Bharathi1, Ganapathy Dhanraj2, Venkatesa Prabhu Sundramurthy3
1Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600007, India.
Microbial Pathogenesis
|May 11, 2025
Summary
Dental biofilm, a resilient bacterial community, causes prevalent oral diseases. This review examines biofilm development and strategies for its management, focusing on promising enzymatic agents like Dispersin B and glucanohydrolases.
Area of Science:
- Oral microbiology
- Biochemistry
- Biotechnology
Background:
- Dental biofilm forms via bacterial adhesion, proliferation, and extracellular polymeric substance secretion.
- The resulting multispecies community is encased in a resilient matrix, conferring resistance to mechanical, immune, and antimicrobial challenges.
- Dental biofilm-associated diseases are highly prevalent, underscoring the need for effective management strategies.
Purpose of the Study:
- To review the complex progression of dental biofilm development.
- To evaluate diverse strategies for dental biofilm management.
- To highlight the potential of enzymatic agents in disrupting biofilm structure.
Main Methods:
- Literature review of dental biofilm formation.
- Analysis of conventional and advanced biofilm management strategies.
- Focus on enzymatic agents, including Dispersin B, DNAases, mutanase, and dextranase.
Main Results:
- Dental biofilm is a structured, resistant community.
- A wide array of management strategies exist, from antibiotics to novel approaches.
- Enzymatic agents demonstrate significant potential in breaking down the biofilm matrix.
Conclusions:
- Effective dental biofilm management is crucial for oral health.
- Enzymatic agents offer a promising therapeutic avenue for biofilm disruption.
- Further research into enzymes like Dispersin B and glucanohydrolases is warranted.
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