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[Hereditary Leukoencephalopathy: Overview to Definition, Diagnosis and Treatment]
Shin Koide1, Shoichiro Ando, Osamu Onodera
1Department of Neurology, Brain Research Institute, Niigata University.
Abstract:
Hereditary leukoencephalopathies represent a heterogeneous group of inherited disorders characterized by abnormalities in the white matter of the brain. Recent advances in neuroimaging and genetic analyses have deepened our understanding of the underlying pathologies, leading to refined classification and diagnostic frameworks. Although many have no curative therapy, new treatments, such as hematopoietic stem cell transplantation, offer promising prospects for some of these diseases. Early and accurate diagnosis is critically important as it may improve management strategies and ultimately enhance patient outcomes.
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