Related Experiment Video
Updated: May 13, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Metastatic Breast Cancer Presenting as Clival Mass Extending into Sphenoid Sinus
Ahmed Nadeem-Tariq1, Taimur Khalid1, Emily S Sagalow1
1Department of Otolaryngology-Head & Neck Surgery, University of Nevada, Las Vegas, USA.
Abstract:
Metastasis to the clivus and sphenoid sinus from breast cancer is exceedingly rare, with few cases documented in the literature. This case report presents a 68-year-old female with a history of breast cancer who developed metastasis to the clivus extending into the sphenoid sinus. The clinical presentation, diagnostic challenges, and therapeutic interventions are discussed, with a review of similar cases in the literature to highlight the importance of early recognition and multidisciplinary management.
Related Concept Videos
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

