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A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy
Lin Jing1, Wenguang Xiao1, Zhouxing Hu1
1Guangxi Key Laboratory of Special Biomedicine; School of Medicine, Guangxi University, Nanning, 530004, People's Republic of China.
Abstract:
Glioma, a highly malignant central nervous system tumor, exhibits aggressive invasiveness, extensive infiltration, and poor prognosis. Conventional treatments such as surgery, radiotherapy, and chemotherapy are hindered by limitations including the inability to overcome the blood-brain barrier (BBB), drug resistance, and high recurrence rates. Ferroptosis induced by nanoparticle-based systems offers an innovative strategy for glioma therapy by efficiently traversing the BBB, precisely delivering ferroptosis inducers, enhancing tumor accumulation, and enabling stimuli-responsive drug release. These features collectively improve the induction efficiency of ferroptosis in glioma cells. Various nanoplatforms, including inorganic nanoparticles, biomimetic carriers, and polymer-based systems, have demonstrated potential in crossing the BBB, inducing ferroptosis, and suppressing glioma progression. These systems enhance reactive oxygen species generation, deplete glutathione, and disrupt tumor microenvironment defense mechanisms, achieving synergistic therapeutic effects. The integration of ferroptosis with nanotechnology is emerging as a promising, non-invasive strategy for the treatment of gliomas, offering substantial therapeutic potential.
Insights
Nanoparticle-based ferroptosis induction is a promising strategy for treating aggressive gliomas. These systems effectively cross the blood-brain barrier, delivering therapies and improving treatment outcomes for this challenging central nervous system tumor.
Area of Science:
- Oncology
- Nanotechnology
- Biomedical Engineering
Background:
- Glioma is a malignant brain tumor with poor prognosis, limited by conventional treatments' inability to cross the blood-brain barrier (BBB).
- Existing therapies face challenges like drug resistance and high recurrence rates, necessitating novel therapeutic strategies.
Purpose of the Study:
- To explore ferroptosis induction via nanoparticle-based systems as an innovative strategy for glioma treatment.
- To evaluate the potential of various nanoplatforms in overcoming BBB limitations and enhancing therapeutic efficacy.
Main Methods:
- Utilized nanoparticle-based systems designed to traverse the BBB and deliver ferroptosis inducers.
- Investigated inorganic nanoparticles, biomimetic carriers, and polymer-based systems for glioma therapy.
- Assessed the enhancement of reactive oxygen species generation and glutathione depletion.
Main Results:
- Nanoparticle systems demonstrated efficient BBB crossing and targeted delivery of ferroptosis inducers.
- Various nanoplatforms showed potential in suppressing glioma progression by inducing ferroptosis.
- Synergistic therapeutic effects were achieved by disrupting tumor microenvironment defense mechanisms.
Conclusions:
- Ferroptosis induction using nanotechnology presents a promising, non-invasive approach for glioma treatment.
- Nanoparticle-based systems offer enhanced delivery, accumulation, and stimuli-responsive release for improved therapeutic outcomes.
- This integrated strategy holds substantial potential for overcoming current limitations in glioma therapy.
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