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Bariatric Surgery for a Patient With Myosin Heavy Chain 9-Related Disorders (MYH9RD): A Case Report

Sa-Hong Kim1, Kyoyoung Park1, Chungyoon Kim1

  • 1Department of Surgery, Seoul National University Hospital, Seoul, Korea.

Journal of Metabolic and Bariatric Surgery
|May 12, 2025
PubMed

Insights

Myosin heavy chain 9-related disorders (MYH9RD) patients with morbid obesity can safely undergo bariatric surgery. Careful preoperative assessment and management enabled successful laparoscopic sleeve gastrectomy and significant health improvements.

Area of Science:

  • Genetics and Medicine
  • Nephrology
  • Bariatric Surgery

Background:

  • Myosin heavy chain 9-related disorders (MYH9RD) are rare genetic conditions characterized by macrothrombocytopenia and renal issues like focal segmental glomerulosclerosis (FSGS).
  • Morbid obesity presents significant surgical risks, particularly in patients with pre-existing bleeding tendencies and renal impairment.

Observation:

  • A 28-year-old male with MYH9RD and a BMI >47 kg/m² underwent laparoscopic sleeve gastrectomy.
  • Preoperative management included platelet transfusions to address macrothrombocytopenia and bleeding risks.
  • The patient had pre-existing renal impairment due to FSGS.

Findings:

  • The surgery proceeded without complications, demonstrating the feasibility of bariatric procedures in MYH9RD patients.
  • Significant weight loss (147.6 kg to 90.15 kg in 1 year) was achieved.
  • Postoperative improvements were noted in hypertension, liver enzymes, HbA1c, triglycerides, and LDL levels.

Implications:

  • This case underscores the importance of meticulous preoperative evaluation and risk mitigation strategies for MYH9RD patients considering bariatric surgery.
  • Comprehensive management can lead to successful surgical outcomes and substantial health benefits in this complex patient population.
  • While not directly linked, MYH9RD management should consider the potential benefits of weight loss in obese individuals.

Keywords:
Bariatric surgeryMYH9-related disordersMorbid obesity

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