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Pulmonary Injury Induced via Metal-Organic Frameworks (MOFs): ROS Generation and Inflammatory Responses Mediated by
Yule Zhang1,2, Zhiwei Xue1, Zhijin Yang1,2
1Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.
ACS Omega
|May 12, 2025
Summary
Metal-organic frameworks (MOFs) show promise in medicine, but their safety is unclear. HKUST-1 MOFs caused lung cell damage due to copper, while UiO-66 and ZIF-8 were safe, indicating a need for toxicity assessment.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Metal-organic frameworks (MOFs) are advanced materials with tunable properties.
- MOFs show potential in drug delivery, diagnostics, and medical imaging.
- Pulmonary toxicity and long-term effects of MOFs require further investigation.
Purpose of the Study:
- To investigate the pulmonary toxicity of UiO-66, ZIF-8, and HKUST-1 MOFs.
- To explore the mechanisms of oxidative stress and inflammation induced by MOFs.
- To assess the safety of MOFs for biomedical applications.
Main Methods:
- In vitro and in vivo assays were used to evaluate MOF toxicity.
- Cytotoxicity, oxidative stress, and apoptosis in lung cells were measured.
- The role of metal ion release in MOF toxicity was examined.
Main Results:
- HKUST-1 induced significant cytotoxicity, oxidative stress, and apoptosis in lung cells.
- Copper content in HKUST-1 was identified as the primary cause of toxicity.
- UiO-66 and ZIF-8 exhibited minimal pulmonary toxicity.
Conclusions:
- Understanding MOF toxicological profiles is crucial for biomedical applications.
- MOF structural modification is necessary to enhance safety.
- HKUST-1's toxicity necessitates careful consideration for its use in medicine.
