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Published on: February 28, 2021
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Baclofen-Induced Pancreatitis
Nicolas Nassif1, Nadia Katrib1, Karam Karam2
1Department of Internal Medicine, University of Balamand, Beirut, Lebanon.
Summary
This case study suggests a probable link between baclofen and acute pancreatitis, a rare drug-induced condition. Physicians should consider baclofen as a potential cause of unexplained pancreatitis.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Acute pancreatitis is an inflammatory pancreatic condition with diverse causes.
- Drug-induced pancreatitis is a rare but significant etiology.
- Common causes include alcohol, gallstones, and trauma.
Purpose of the Study:
- To report a case of acute pancreatitis potentially induced by baclofen.
- To highlight the importance of considering baclofen in drug-induced pancreatitis differential diagnoses.
Main Methods:
- Case report detailing a patient who developed acute pancreatitis after initiating baclofen.
- Utilized the Naranjo Adverse Drug Reaction Probability Scale to assess causality.
- Ruled out common causes of pancreatitis.
Main Results:
- A probable association between baclofen therapy and acute pancreatitis was identified.
- The patient presented with characteristic symptoms and elevated pancreatic enzymes.
Conclusions:
- Baclofen should be considered a potential cause of acute pancreatitis.
- Clinicians must maintain a high index of suspicion for drug-induced pancreatitis when baclofen is prescribed.
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