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Related Experiment Video

Updated: May 13, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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IL-17A, IL-17F, and IL-23 in Patients with Rheumatoid Arthritis.

N A Lapkina1, A A Baranov2, O P Rechkina2

  • 1Yaroslavl State Medical University, Yaroslavl, Russia. lanaal@rambler.ru.

Doklady. Biochemistry and Biophysics
|May 12, 2025
PubMed
Summary
This summary is machine-generated.

In advanced rheumatoid arthritis (RA), elevated Interleukin-23 (IL-23) is common, while IL-17A and IL-17F levels are similar to controls. High IL-17A correlates with disease activity indices and autoantibodies.

Keywords:
IL-17AIL-17FIL-23disease activityrheumatoid arthritis

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Area of Science:

  • Immunology
  • Rheumatology
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
  • Interleukins (ILs) play a crucial role in RA pathogenesis, with IL-17 and IL-23 pathways being key targets.
  • Understanding the specific roles of IL-17A, IL-17F, and IL-23 in advanced RA is important for targeted therapies.

Purpose of the Study:

  • To evaluate the clinical and diagnostic significance of IL-17A, IL-17F, and IL-23 in patients with advanced RA.
  • To compare serum cytokine levels in RA patients with healthy controls.
  • To investigate correlations between these cytokines and RA disease activity markers.

Main Methods:

  • Serum samples from 154 RA patients (ACR/EULAR 2010 criteria) and 20 healthy donors were analyzed.
  • Multiplex xMAR technology was used to quantify IL-17A, IL-17F, and IL-23 levels.
  • Clinical data, including disease activity scores (DAS28-ESR, CDAI, SDAI), rheumatoid factor (IgM RF), and anti-cyclic citrullinated peptide antibodies (ACCP), were collected.

Main Results:

  • Serum IL-23 levels were significantly higher in RA patients compared to controls (p < 0.05).
  • IL-17A and IL-17F levels did not significantly differ between RA patients and controls (p > 0.05).
  • Elevated IL-17A correlated with higher CDAI, SDAI, IgM RF, and ACCP. Elevated IL-17F correlated with higher ESR and CRP. High IL-23 was associated with lower HR (p < 0.05).

Conclusions:

  • IL-23 is significantly elevated in advanced RA patients, suggesting its involvement in disease progression.
  • While IL-17A and IL-17F levels may not differ from controls, elevated IL-17A shows associations with disease activity and serological markers.
  • IL-17F overproduction is more frequent than IL-17A elevation in advanced RA, and combined cytokine overproduction does not amplify individual pro-inflammatory effects.