Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary aldosteronism: computerized tomography in preoperative evaluation.

P W Balkin, J W Hollifield, S D Winn

    Southern Medical Journal
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stent-graft arteriovenous fistula: an endovascular technique in hemodialysis access.

    Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery·1998
    Same author

    Treatment of malignant obstruction of the right ventricular outflow tract and pulmonary artery with metallic stents.

    AJR. American journal of roentgenology·1997
    Same author

    Abdominal case of the day. Superior mesenteric venous thrombosis.

    AJR. American journal of roentgenology·1992
    Same author

    Abdominal case of the day. Complicated appendicitis.

    AJR. American journal of roentgenology·1992
    Same author

    Abdominal case of the day. Gastric adenocarcinoma.

    AJR. American journal of roentgenology·1992
    Same author

    The effects of benazepril, a new angiotensin-converting enzyme inhibitor, in mild to moderate essential hypertension: a multicenter study.

    Clinical pharmacology and therapeutics·1991
    Same journal

    SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

    Southern medical journal·2026
    Same journal

    Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

    Southern medical journal·2026
    Same journal

    Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

    Southern medical journal·2026
    Same journal

    Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

    Southern medical journal·2026
    Same journal

    Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

    Southern medical journal·2026
    Same journal

    Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

    Southern medical journal·2026
    See all related articles

    Computerized tomography (CT) shows low sensitivity but high specificity for diagnosing primary aldosteronism. While CT accuracy improved slightly with newer scanners, it remains less effective for smaller tumors.

    Area of Science:

    • Endocrinology
    • Radiology
    • Surgical Pathology

    Background:

    • Primary aldosteronism, also known as Conn's syndrome, is a condition characterized by excessive aldosterone secretion.
    • Accurate preoperative evaluation is crucial for effective surgical management of primary aldosteronism.

    Purpose of the Study:

    • To evaluate the diagnostic value of computerized tomography (CT) in the preoperative assessment of patients with primary aldosteronism.
    • To determine the sensitivity and specificity of CT in identifying diseased and normal adrenal glands.

    Main Methods:

    • A retrospective review of 34 patients with primary aldosteronism.
    • Standardized protocol including saline suppression testing, abdominal CT scanning, and adrenal venous sampling.
    • Evaluation of 68 adrenal glands based on surgical pathology, biochemical data, and clinical response to adrenalectomy.

    Related Experiment Videos

    Main Results:

    • CT correctly identified 48% of diseased adrenal glands and 91% of normal glands.
    • CT demonstrated low sensitivity (0.48) but high specificity (0.91) for Conn's syndrome.
    • Improved CT sensitivity (0.58 vs. 0.42) was observed with a high-resolution scanner, but specificity remained similar (0.92 vs. 0.90).
    • CT sensitivity was lower for smaller tumors compared to larger ones.

    Conclusions:

    • Computerized tomography is a specific but not highly sensitive tool for preoperative evaluation in primary aldosteronism.
    • Advancements in CT technology showed marginal improvements in sensitivity.
    • CT's effectiveness is limited by tumor size, necessitating consideration of other diagnostic modalities.