Vibrational circular dichroism beyond solutions

Area of Science:

• Spectroscopy
• Chiroptical techniques
• Solid-state chemistry

Background:

• Vibrational circular dichroism (VCD) spectroscopy is a powerful tool, widely used for absolute configuration determination in solution.
• Applications of VCD to solid-state samples are less common due to significant methodological and theoretical hurdles.
• Early solid-state VCD experiments faced challenges that limited widespread adoption.

Purpose of the Study:

• To provide a comprehensive review of solid-state VCD spectroscopy applications.
• To examine the historical development and methodological advancements in the field.
• To outline current challenges and future prospects for solid-state VCD.

Main Methods:

• Review of existing literature on solid-state VCD experiments.
• Categorization of various solid-state VCD experimental approaches.
• Overview of theoretical methodologies supporting experimental developments.

Main Results:

• Solid-state VCD, despite challenges, has seen diverse experimental explorations.
• A historical perspective reveals the evolution of techniques and applications.
• Key challenges and theoretical underpinnings of solid-state VCD are identified.

Conclusions:

• Solid-state VCD spectroscopy offers unique insights but requires overcoming methodological and theoretical complexities.
• The review highlights the potential for broader application of VCD in solid-state analysis.
• Future developments are anticipated to enhance the accessibility and utility of solid-state VCD.