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Updated: May 22, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Influences of variations of the amount of compressed material on compressibility, tabletability and compactability
Anh Tuan Tran1, Stefan Klinken-Uth1
1Heinrich Heine University Düsseldorf, Faculty of Mathematics and Natural Science, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Abstract:
Compression analysis is essential for the investigation of materials and processes in the manufacturing of pharmaceutical tablets. In the past, the influence of various process parameters on compression analysis has been investigated. The strength of these influences can significantly depend on the properties of the compressed material. One example is the effect of tablet compression speed on tabletability. The impact of tablet geometry has also been studied. However, what is still missing in the literature is the investigation of the influence of the quantity of the compressed material. This publication provides a starting point for understanding the effect of material quantity in compression analysis. In addition to the material quantity, two different tablet diameters were also investigated. The study demonstrates that the extent to which material quantity has an influence on compression analysis highly depends on the material properties. It clearly shows that the tabletability and even the compactability of materials can vary significantly depending on the amount of material compressed.
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