Circulating adipokines in girls with central precocious puberty: A systematic review and meta-analysis

This meta-analysis aimed to assess circulating adipokine levels in girls with central precocious puberty (CPP) and compare them with those in healthy controls.

An exhaustive literature search was conducted, using the Embase, PubMed, Web of Science, Cochrane Library, and Scopus databases, from the inception of the study to October 31, 2023, to identify relevant studies. Studies comparing the serum levels of adiponectin, leptin, irisin, apelin, omentin,chemerin, resistin, vaspin, and visfatin in girls with CPP and healthy girls of the same age were included. The findings were summarized in Grading of Recommendations Assessment, Development, and Evaluation evidence profiles and synthesized qualitatively.

Eleven studies that included 701 girls with CPP and 590 healthy girls were analyzed after the selection process. Leptin levels were significantly increased, whereas adiponectin levels were decreased in girls with CPP. Irisin levels did not change significantly. Subgroup and meta-regression analyses indicated that the heterogeneity in the association of leptin with CPP might be due to factors such as the number of cases, diagnostic criteria for CPP, and measurement methods.

Adipokines levels were altered in girls with CPP compared with those in healthy controls. Preventing obesity in children and adolescents with CPP is crucial.

CRD42022371490.

This meta-analysis is the first to explore the relationship between adipokines and central precocious puberty. The results of this systematic review provide evidence that adipokines levels are altered in girls with central precocious puberty (CPP) compared with those in healthy controls. CPP in girls increases the risk of cardiovascular disease in adulthood. Preventing obesity in children and adolescents, especially in those with precocious puberty, is crucial.