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Related Experiment Video

Updated: May 16, 2025

fMRI Validation of fNIRS Measurements During a Naturalistic Task
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Wearable fNIRS platform for dense sampling and precision functional neuroimaging.

Ali Rahimpour Jounghani1, Anupam Kumar2, Laura Moreno Carbonell1,3

  • 1Department of Psychiatry and Behavioral Sciences, School of Medicine, Computational Brain Research and Intervention (C-BRAIN) Laboratory, Stanford University, Palo Alto, CA, USA.

NPJ Digital Medicine
|May 12, 2025
PubMed
Summary

A new wearable functional near-infrared spectroscopy (fNIRS) platform shows promise for precision mental health. It reliably captures individualized brain connectivity, supporting tailored interventions.

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Area of Science:

  • Neuroscience
  • Medical Technology
  • Mental Health

Background:

  • Precision mental health seeks to personalize interventions using individual neurobiological data.
  • Functional near-infrared spectroscopy (fNIRS) offers a portable and cost-effective neuroimaging alternative.

Purpose of the Study:

  • To evaluate a self-administered, wearable fNIRS platform for precision mental health.
  • To assess the platform's reliability and specificity in capturing individualized functional connectivity.

Main Methods:

  • A wireless, multichannel fNIRS device with augmented reality guidance for placement.
  • Cloud-based system for remote data access.
  • Eight adults underwent ten dense-sampled sessions with cognitive tasks and resting-state measurements.

Main Results:

  • High test-retest reliability in functional connectivity and activation patterns.
  • Consistent within-participant functional connectivity and activation.
  • Demonstrated feasibility for individualized functional mapping.

Conclusions:

  • The wearable fNIRS platform is a feasible tool for individualized functional brain mapping in precision mental health.
  • Further research with larger, diverse cohorts, including clinical populations, is warranted to explore disorder-specific applications.